Simultaneous Determination of Metoprolol-Hydrochlorothiazide and Propranolol-Hydrochlorothiazide in Combined Formulations by Derivative Spectroscopy
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چکیده
منابع مشابه
Simultaneous Determination of Losartan and Hydrochlorothiazide in Pharmaceutical Preparations by Derivative and Ratio Derivative Spectrophotometry
Background & Aims: Losartan is a non-peptide potent antihypertensive agent that acts through blocking angiotensin II receptors. Hyzaar® is a combination product that contains two drugs, losartan and hydrochlorothiazide, used to lower high blood pressure. There are some reports regarding simultaneous measurement of the drugs in pharmaceutical and biological samples which includes HPLC, CE, CEC, ...
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This paper describes a method for quantitative spot test analysis of hydrochlorothiazide using diffuse reflectance spectroscopy. The reflectance measurements were performed analyzing the colored compound (l = 585 nm) produced from the reaction between hydrochlorothiazide and pdimethylaminocinnamaldehyde (PDAC) in acid medium. This reaction occurred on filter paper after heating to 80oC for 8 mi...
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A new Fourier Transform-Infra Red (FT-IR) spectrometric method was developed for assaying hydrochlorothiazide (HCT) and enalapril maleate (ENM) in binary solid pharmaceutical formulations. Multivariate Partial Least Squares (PLS) method was used for calibration of derivative spectral data. Acetonitrile was used as solvent due to its spectral tran...
متن کاملDetermination of metoprolol and hydrochlorothiazide by derivative spectrophotometric method in pharmaceutical preparations.
A procedure for simultaneous determination of metoprolol and hydrochlorothiazide in tablets by employing derivative spectrophotometry, "zero-crossing" method was developed. The third order derivative absorption spectra at lambda approximately 281 nm were used for metoprolol and the first order derivative spectra at lambda approximately 282 nm were used for hydrochlorothiazide. No interferences ...
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Metoprolol tartrate (MT) (Figure 1) is a selective adrenergic antagonist that is devoid of intrinsic sympathomimetic activity [1]. It is used in the management of hypertension, angina pectoris, cardiac arrhythmia, and myocardial infarction [2]. Hydrochlorothiazide (HZ) (Figure 1) is a thiazide diuretic that is used in the treatment of hypertension, either alone or with other antihypertensives. ...
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ژورنال
عنوان ژورنال: Journal of AOAC INTERNATIONAL
سال: 1997
ISSN: 1060-3271,1944-7922
DOI: 10.1093/jaoac/80.2.325